Hyaluronan, a beneficial glycosaminoglycan that may affect the phenotype of cardiac hypertrophy – a hypothesis
DOI:
https://doi.org/10.17987/icfj.v1i5.62Abstract
Myocardial hypertrophy contribute to ventricular diastolic dysfunction and can lead to heart failure, arrhythmia and evensudden death. It have been shown that during development of hypertrophy the concentration of the glycosaminoglycan
hyaluronan increases. The increased concentration correlates to the increased gene expression of fetal and extracellular
matrix genes that is associated with cardiac remodeling.
Moreover it has been shown that high molecular weight hyaluronan depolarize the membrane potential of cells.
The increase of hyaluronan in cardiac hypertrophy could hypothetically affect the resting membrane potential in
cardiomyocytes and thus affect the conduction through the heart.
Hypothesis. The role of hyaluronan as a molecule adapting the extracellular matrix when the heart is growing could potentially
develop to be harmful to cardiomyocyte resting membrane potential and hence contribute to the risk of arrhythmia.
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
a. The authors will retain copyright under a Creative Commons Attribution License (CC-BY 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
