Hyaluronan, a beneficial glycosaminoglycan that may affect the phenotype of cardiac hypertrophy – a hypothesis
AbstractMyocardial hypertrophy contribute to ventricular diastolic dysfunction and can lead to heart failure, arrhythmia and even
sudden death. It have been shown that during development of hypertrophy the concentration of the glycosaminoglycan
hyaluronan increases. The increased concentration correlates to the increased gene expression of fetal and extracellular
matrix genes that is associated with cardiac remodeling.
Moreover it has been shown that high molecular weight hyaluronan depolarize the membrane potential of cells.
The increase of hyaluronan in cardiac hypertrophy could hypothetically affect the resting membrane potential in
cardiomyocytes and thus affect the conduction through the heart.
Hypothesis. The role of hyaluronan as a molecule adapting the extracellular matrix when the heart is growing could potentially
develop to be harmful to cardiomyocyte resting membrane potential and hence contribute to the risk of arrhythmia.
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