Takotsubo Syndrome: A Complex and Varied Clinical Syndrome


  • Louise Shewan
  • Michael Henein
  • Andrew Coats Editor-in-Chief, J.ATAMIS, Academic Vice-President, Monash University, Australia and University of Warwick, UK http://orcid.org/0000-0002-2771-4260




Takotsubo Cardiomyopathy, Review, Diagnosis, Acute Coronary Syndromes


This special issue includes expert reviews and original research on Takotsubo syndrome (TTS) including the history of its identification and the unravelling of the pathophysiology of the different variants of the syndrome. The role of neurological stress or catecholaminergic overload are reviewed, as is the role of CNS disorders triggering TTS. Clinical presentation patterns of TTS and the most useful diagnostic tests are reviewed, including original research into a novel clinical score the ‘GET QT' score to help in rapid differentiation of TTS from STEMI. There is also a review of TTS in the intensive care unit setting.  The mechanisms of TTS including the role and assessment of the microcirculation in generating the classical myocardial dysfunction are reviewed in detail, as are the pathophysiological pathways of recurrent TTS. Lastly Singh, Akashi and Horowitz review the emerging treatment options for TTS. They issue also includes multiple elegant and fascinating case reports. TTS has come of age and now urgently adequate sized RCT’s.  

Author Biography

Andrew Coats, Editor-in-Chief, J.ATAMIS, Academic Vice-President, Monash University, Australia and University of Warwick, UK

Andrew holds a MB and BChir from Cambridge, an MA and DM from Oxford, a DSc. from Imperial College, and an MBA from London Business School. Andrew served as the Inaugural Viscount Royston Professor of Cardiology at the National Heart and Lung Institute in London, as Director of Cardiology of the Royal Brompton and Harefield NHS trust as Head of Clinical Cardiology at Imperial College, as Dean of Medicine at the University of Sydney, as Deputy Vice-Chancellor of Sydney, and as CEO of the Norwich Research Park. He is presently Academic Vice-President of Monash University, Australia and the University of Warwick, UK and Director of the Monash-Warwick Alliance.

Andrew has published in excess of 1400 publications and has more than 52,000 career citations, and a personal H-index of 106. He has been Editor-in-Chief of the International Journal of Cardiology since 1999 and has received the Linacre Medal of the Royal College of Physicians and the inaugural Michael L Pollock award of the American Heart Association. He has been Chairman or Committee member of the following major Cardiovascular Trials: CHRISTMAS, CHARM, COPERNICUS, OXAM, OPTIMAAL, OVERTURE, REPLACE and SENIORS. Andrew also has more than 20 patents, and has two successful spin-out companies which have generated more than £30Million in investment.  

Andrew has more than 30 board years of experience as a director across the health and biotechnology, sectors (including Myotec, PsiOxus, Cardiodirect, Primary Heart Care, Lone Star Heart Inc, the Harley Street Group) and in the not-for-profit sector (including the George Institute, the Centenary Institute, ANZAC Institute of Medical Research, Sydney Cancer Centre Foundation, Colney Innovations Limited, and the Woolcock Institute of Medical Research).


Shewan LG, Coats AJS, Henein M. Requirements for ethical publishing in biomedical journals. International Cardiovascular Forum Journal 2015;2:2 DOI: 10.17987/icfj.v2i1.4