Takotsubo cardiomyopathy associated with the administration of intranasal phenylephrine/lignocaine for epistaxis





Takotsubo, pharmacology, vasospasm


Sato H, Tateishi H, Uchida T. Takotsubo-type cardiomyopathy due to multivessel spasm. In: Kodama K, Haze K, Hon M, eds. Clinical Aspect of Myocardial Injury: From Ischemia to Heart Failure. Tokyo: Kagakuhyouronsha; 1990:56-64.

Spina R, Feneley M. A stressful angiogram: acute takotsubo cardiomyopathy. J. Am. Coll. Cardiol. 2014;63(20):e53. doi:10.1016/j.jacc.2014.01.074.

Kugiyama K, Ohgushi M, Motoyama T, et al. Enhancement of constrictor response of spastic coronary arteries to acetylcholine but not to phenylephrine in patients with coronary spastic angina. J. Cardiovasc. Pharmacol. 1999;33(3):414-9. Available at: http://www.ncbi.nlm.nih.gov/pubmed/10069677. Accessed May 30, 2015.

Ashchi M, Wiedemann HP, James KB. Cardiac complication from use of cocaine and phenylephrine in nasal septoplasty. Arch. Otolaryngol. Head. Neck Surg. 1995;121(6):681-4. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7772323. Accessed May 30, 2015.

Higgins TS, Hwang PH, Kingdom TT, Orlandi RR, Stammberger H, Han JK. Systematic review of topical vasoconstrictors in endoscopic sinus surgery. Laryngoscope 2011;121(2):422-32. doi:10.1002/lary.21286.

Littlejohn FC, Syed O, Ornstein E, Connolly ES, Heyer EJ. Takotsubo cardiomyopathy associated with anesthesia: three case reports. Cases J. 2008;1(1):227. doi:10.1186/1757-1626-1-227.

Hussain J, Laufer N, Sorrof S, Pershad A. Takotsubo cardiomyopathy after coronary intervention developed during hospitalization. Ann. Thorac. Surg. 2009;88(6):e63-5. doi:10.1016/j.athoracsur.2009.09.070.

Park I-K, Sir J-J, Jung H-J, Jo S-Y, Cho W-H, Choi S-K. Atypical takotsubo cardiomyopathy associated with nasal packing for paranasal sinus surgery. Eur. J. Echocardiogr. 2010;11(2):186-8. doi:10.1093/ejechocard/jep174.

Scantlebury DC, Prasad A, Rabinstein AA, Best PJM. Prevalence of migraine and Raynaud phenomenon in women with apical ballooning syndrome (Takotsubo or stress cardiomyopathy). Am. J. Cardiol. 2013;111(9):1284-8. doi:10.1016/j.amjcard.2013.01.269.

Gabriel L, Chenu P, Guédès A, et al. A possible association between takotsubo cardiomyopathy and treatment with flecainide. Int. J. Cardiol. 2011;147(1):173-5. doi:10.1016/j.ijcard.2010.12.023.

Shewan LG, Coats AJS, Henein M. Requirements for ethical publishing in biomedical journals. International Cardiovascular Forum Journal 2015;2:2 DOI: 10.17987/icfj.v2i1.4






Letters to the Editor