Tako-tsubo Cardiomyopathy following Bronchial Asthma Attack


  • Cengiz Ozturk
  • Ali Osman Yildirim
  • Sevket Balta
  • Mustafa Demir
  • Siddik Erdogan
  • Turgay Celik
  • Atila Iyisoy




Tako-tsubo cardiomyopathy, bronchial asthma attack


Takotsubo cardiomyopathy(TCM) is a reversible cardiomyopathy characterized by left ventricular  dysfunction  due  to  transient  left  ventricular  apical hypokinesia  or  akinesia  and basal hyperkinesis following some trigger factors like physical  or emotional stressful events and  may mimic myocardial infarction  especially in middle age females.  Pathophysiology of TCM  is  not  clear  but  it  is  associated  with  excessive  adrenergic  stimulation[1-3].  TCM  is usually  precipitated  by  acute  physical  and  emotional  stresssors,  use  of  exogenous
catecholamines or exacerbation of chronic illnesses like asthma attack. We report a case of  TCM  after  an  asthma  attack  as  a  potential  stressor.  This  is  an  interesting  association between asthma attack and TCM.


T.M. Pilgrim, T.R. Wyss, Takotsubo cardiomyopathy or transient left ventricular apical ballooning syndrome: a systematic review, Int. J. Cardiol. 124 (3) (Mar 14 2008) 283–292. doi:10.1016/j.ijcard.2007.07.002

Biteker M, Duran NE, Gökdeniz T, Gündüz S, Güler A, Kaya H, Yildiz M, Ozkan M. Takotsubo cardiomyopathy mimicking acute high lateral myocardial infarction. Anadolu Kardiyol Derg. 2010 Feb 15;10(1):E2-3.

Akyüz AR, Korkmaz L, Turan T, Varlıbaş A. Which is first? Whether Takotsubo cardiomyopathy was complicated with acute stroke or acute stroke caused Takotsubo cardiomyopathy? A case report. Anadolu Kardiyol Derg. 2014 Nov;14(7):648-9. doi: 10.5152/akd.2014.5497.

Santoro F, Correale M, Ieva R, Caiaffa MF, Pappalardo I, Di Biase M, Brunetti ND.Tako-tsubo cardiomyopathy following an allergic asthma attack after cephalosporin administration. Int J Cardiol. 2012 Aug 9;159(1):e20-1. doi:10.1016/j.ijcard.2011.11.106.

Sarkar S, Arguelles E, de Elia C.Takosubo cardiomyopathy presenting as a non-ST segment elevation myocardial infarction in the setting of cocaine use and asthma exacerbation. Int J Cardiol. 2013 Sep 20;168(1):e1-2. doi: 10.1016/j.ijcard.2013.04.191.

Rennyson SL, Parker JM, Symanski JD, Littmann L. Recurrent, severe, and rapidly reversible apical ballooning syndrome in status asthmaticus. Heart Lung. 2010 NovDec;39(6):537-9. doi: 10.1016/j.hrtlng.2009.11.004.

Marmoush FY, Barbour MF, Noonan TE, Al-Qadi MO. Takotsubo Cardiomyopathy: A New Perspective in Asthma. Case Rep Cardiol. 2015;2015:640795. doi: 10.1155/2015/640795.

Badouin A, Bastien O. ECLS indication for a case of stress myocardiopathy associated with severe asthma. Anaesth Crit Care Pain Med. 2015 Jun;34(3):179-81. doi:10.1016/j.accpm.2014.10.002.

Stanojevic DA, Alla VM, Lynch JD, Hunter CB. Case of reverse takotsubo cardiomyopathy in status asthmaticus. South Med J. 2010 Sep;103(9):964. doi:


Osuorji I, Williams C, Hessney J, Patel T, Hsi D. Acute stress cardiomyopathy following treatment of status asthmaticus. South Med J. 2009 Mar;102(3):301-3. doi:10.1097/SMJ.0b013e31818f5bd8.

Shewan L.G., Coats A.J.S., Henein M. Requirements for Ethical Publishing in Biomedical Journals. International Cardiovascular Forum Journal. 2015;2:2. http://dx.doi.org/10.17987/icfj.v2i1.4






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