Clinical Experience of Dabigatran and Rivaroxaban in Electrical Cardioversion of Atrial Fibrillation

Authors

Charlène Coquard Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France Telephone: +33.1.49.95.86.74 Fax: +33.1.49.95.84.39 Email: charlene-coquard@hotmail.fr
Ghassan Moubarak Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France
Mathilde Baudet Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France
Damien Logeart Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France
Jean-Guillaume Dillinger Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France
Alain Cohen-Solal Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France

DOI:

https://doi.org/10.17987/icfj.v4i0.148

Keywords:

Atrial Fibrillation, Electrical Cardioversion, Novel oral anticoagulants, Stroke

Abstract

Patients scheduled for atrial fibrillation (AF) cardioversion were excluded from clinical trials of novel oral anticoagulants (NOACs).

We evaluated efficacy and safety of NOACs in patients undergoing electrical cardioversion for AF.

We performed a monocentric study of all patients on NOACs who underwent elective electrical cardioversion for non-valvular AF between January 2012 and December 2014. We analyzed incidence of stroke and bleeding at 30 days.

Fifty patients were included, 28 receiving dabigatran, 22 rivaroxaban. Mean age was 65 ± 12 years. Mean CHADS2-VA2SC and HASBLED scores were 3 ± 1.8 and 2.2 ± 1.1 respectively. Transoesophageal echocardiography was performed in 41 (79%) patients, revealing a thrombus in 2 (5%). No clinical evidence of stroke occurred in the 30 days, 1 major gastrointestinal bleeding (2%) in patient on rivaroxaban (led to premature discontinuation) and 3 minor bleedings.

NOACs seem to be safe in daily practice of electrical cardioversion in our population.

Author Biographies

Charlène Coquard, Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France Telephone: +33.1.49.95.86.74 Fax: +33.1.49.95.84.39 Email: charlene-coquard@hotmail.fr

2 rue Ambroise Paré, 75010 Paris, France

Telephone: +33.1.49.95.86.74

Fax: +33.1.49.95.84.39

Email: charlene-coquard@hotmail.fr

Ghassan Moubarak, Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France

2 rue Ambroise Paré, 75010 Paris, France

Telephone: +33.1.49.95.86.74

Fax: +33.1.49.95.84.39

Mathilde Baudet, Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France

2 rue Ambroise Paré, 75010 Paris, France

Telephone: +33.1.49.95.86.74

Fax: +33.1.49.95.84.39

Damien Logeart, Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France

2 rue Ambroise Paré, 75010 Paris, France

Telephone: +33.1.49.95.86.74

Fax: +33.1.49.95.84.39

Jean-Guillaume Dillinger, Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France

2 rue Ambroise Paré, 75010 Paris, France

Telephone: +33.1.49.95.86.74

Fax: +33.1.49.95.84.39

Alain Cohen-Solal, Department of Cardiology, Lariboisière Hospital, Paris Diderot University, INSERM UMR-S 942, Paris, France 2 rue Ambroise Paré, 75010 Paris, France

2 rue Ambroise Paré, 75010 Paris, France

Telephone: +33.1.49.95.86.74

Fax: +33.1.49.95.84.39

References

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Shewan LG, Coats AJS, Henein M. Requirements for ethical publishing in biomedical journals. International Cardiovascular Forum Journal 2015;2:2 DOI: 10.17987/icfj.v2i1.4

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Published

2015-12-04

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